N-Acetyl Cysteine (NAC) and Glycine May Help Improve Key Markers of Aging
GSH is the most abundant antioxidant in your body and plays an important role in health promotion.
The formation of glutathione (GSH) requires both cysteine (from NAC) and glycine, which may be why scientists are now finding GlyNAC supplementation provides a wide range of health benefits not provided by NAC-alone or GSH-alone
GlyNAC supplementation may be a novel nutritional approach to support healthy aging and improve key markers linked with aging, including: muscle strength, exercise capacity, cognition, and body composition.
Here's a review of some resent studies:
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01:00 N-acetylcysteine and glycine are rate limiting amino acids in glutathione production.
01:00 Glutathione is comprised of glutamine, cystine, and glycine.
02:40 Glycine-NAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, ageing hallmarks, metabolic defects, muscle strength, cognitive decline and body composition.
05:20 Taking direct antioxidants has conflicting evidence.
07:30 GGT liver enzyme is a marker of glutathione turnover.
Lizzo, G. et al. A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. Frontiers Aging 3, 852569 (2022).