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Berberine: Metabolic Health Benefits Explained Via the GUT

Berberine: Metabolic Health Benefits Explained Via the GUT

The recent popularity of Ozempic (semaglutide) has finally made “gut hormones” a kitchen-table topic. 

Unlike most stimulant-based fat burners, Ozempic offers it’s metabolic health benefits by way of the gut. 

Berberine HCl has similar indirect effects on metabolic health through its effect on the same gastrointestinal hormones termed “incretins.”

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An analysis of 11 studies were included a meta-analysis looking at the effect of Berberine HCL supplementation, more than 1 gram per day, on waist circumference, finding, "the impact of Berberine HCL on waist circumference was significant in studies conducted on overweight subjects." (1) 

In this video we discuss more about: 

-Berberine's interaction with gut bacteria are known to be an essential mechanistic basis for the health benefits linked with Berberine. 

-Berberine HCl has indirect effects on metabolic health through its effect on the gastrointestinal hormones termed “incretins.”

-Oral Berberine HCl undergoes a conversion-absorption-reversion process that takes place entirely in the intestinal environment.

-Gut bacteria interact with Berberine reducing it to dihydroberberine where it's then oxidized within the intestinal cells back to berberine--the main chemical form detectable in the blood. 

It's important to note that virtually all of the human studies conducted on berberine to date are use Berberine HCl in doses of ~ 500 mg once or twice daily, not dihydroberberine (DHB). 

Although some companies claim 'dihydroberberine (DHB) is 5X better absorbed than Berberine HCl,' DHB is virtually undetectable in blood and organs. 

1.Och, A., Podgórski, R. & Nowak, R. Biological Activity of Berberine—A Summary Update. Toxins 12, 713 (2020).
Figure 1. From Och, A., Podgórski, R. & Nowak, R. Biological Activity of Berberine—A Summary Update. Toxins 12, 713 (2020).

 

References: 

1. Zamani, M. et al. The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Front. Nutr. 9, 1013055 (2022).
2.Xu, X. et al. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed. Pharmacother. 133, 110984 (2021).
3.Cheng, H., Liu, J., Tan, Y., Feng, W. & Peng, C. Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine. J Pharm Analysis 12, 541–555 (2022).
4.Zhao, H., Xing, C., Zhang, J. & He, B. Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis. Reprod. Heal. 18, 171 (2021).