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A six-month protocol of Growth hormone (HGH), DHEA and metformin Slowed Biologic Age


Last fall UCLA’s Steve Horvath, PhD published a study showing that reversal of biologic age was possible.

A six-month protocol of Growth hormone (HGH), DHEA and metformin was able to take 2.5 years off participants’ age.

As cool as it sounds, there’s a logistical downside: HGH is virtually impossible to buy, has side effects and is very expensive.

Since recently discovering that my own biologic age is 2.5 years ahead of my actual age, I’ve been testing various supplements to see how I can slow things down.

Adding Thymus glandular and Berberine HCl to my 25 mg morning DHEA routine seems to help.

Since the pathways supported by these nutrients also incidentally support immune system health*, I thought you may want to know about it.

Here's the protocol that I've been taking and plan to continue for six months then retest my epigenetic age

Morning on Exercise Days:  

25 mg DHEA  **Sometimes I take a few sprays of DHEA pre-workout, too 

*I don’t suggest taking Berberine HCl pre-exercise, it’s a long story :-) 

Evening (after dinner):

1 capsule of Berberine HCl + Alpha Lipoic Acid

3 tablets of Thymus glandular

Morning on Fasting and Non-Exercise Days:  

25 mg DHEA and 3 tablets of Thymus glandular

1-2 capsules of Berberine HCl + Alpha Lipoic Acid

Evening (after dinner):

1 capsule of Berberine HCl + Alpha Lipoic Acid

3 tablets of Thymus glandular

Notes and disclaimers: 

Women should go-low-and-slow with DHEA; starting at 5 mg in the AM and only increasing as needed, slowly. I always suggest testing your DHEA-S levels (serum or via the DUTCH Plus test) to determine if you even need to supplement with DHEA. 

The rationale for taking the Cytozyme thymus later in the day is your immune system is particularly active while you sleep. 


Fahy GM, Brooke RT, Watson JP, et al. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019;18(6):421–12. doi:10.1111/acel.13028.


*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


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